sc13gza

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

(Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED
PURSUANT TO 13d-2(b)

(Amendment No. 1)¹

SenoRx, Inc.

(Name of Issuer)

Common Stock
(Title of Class of Securities)

81724W104
(CUSIP Number)

December 31, 2008
(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

o Rule 13d-1(b)

o Rule 13d-1(c)

þ Rule 13d-1(d)

¹The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).


CUSIP No.		81724W104	13G


1	NAME OF REPORTING PERSON I.R.S. Identification No. of Above Persons (Entities Only) Mayfield IX Management, L.L.C.


2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
	(a) o
	(b) þ

3	SEC USE ONLY



4	CITIZENSHIP OR PLACE OF ORGANIZATION

	Delaware

		5	SOLE VOTING POWER

NUMBER OF			-0-

SHARES		6	SHARED VOTING POWER
BENEFICIALLY
OWNED BY			599,549

EACH		7	SOLE DISPOSITIVE POWER
REPORTING
PERSON			-0-

WITH		8	SHARED DISPOSITIVE POWER

			599,549

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	599,549

10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

	o

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	3.5%

12	TYPE OF REPORTING PERSON

	OO

Page 2 of 16 pages.


CUSIP No.		81724W104	13G


1	NAME OF REPORTING PERSON I.R.S. Identification No. of Above Persons (Entities Only) Mayfield IX, a Delaware Limited Partnership


2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
	(a) o
	(b) þ

3	SEC USE ONLY



4	CITIZENSHIP OR PLACE OF ORGANIZATION

	Delaware

		5	SOLE VOTING POWER

NUMBER OF			-0-

SHARES		6	SHARED VOTING POWER
BENEFICIALLY
OWNED BY			569,574

EACH		7	SOLE DISPOSITIVE POWER
REPORTING
PERSON			-0-

WITH		8	SHARED DISPOSITIVE POWER

			569,574

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	569,574

10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

	o

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	3.3%

12	TYPE OF REPORTING PERSON

	PN

Page 3 of 16 pages.


CUSIP No.		81724W104	13G


1	NAME OF REPORTING PERSON I.R.S. Identification No. of Above Persons (Entities Only) Mayfield Associates Fund IV, a Delaware Limited Partnership


2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
	(a) o
	(b) þ

3	SEC USE ONLY



4	CITIZENSHIP OR PLACE OF ORGANIZATION

	Delaware

		5	SOLE VOTING POWER

NUMBER OF			-0-

SHARES		6	SHARED VOTING POWER
BENEFICIALLY
OWNED BY			29,975

EACH		7	SOLE DISPOSITIVE POWER
REPORTING
PERSON			-0-

WITH		8	SHARED DISPOSITIVE POWER

			29,975

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	29,975

10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

	o

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	0.2%

12	TYPE OF REPORTING PERSON

	PN

Page 4 of 16 pages.


CUSIP No.		81724W104	13G


1	NAME OF REPORTING PERSON I.R.S. Identification No. of Above Persons (Entities Only) Yogen K. Dalal


2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
	(a) o
	(b) þ

3	SEC USE ONLY



4	CITIZENSHIP OR PLACE OF ORGANIZATION

	U.S.

		5	SOLE VOTING POWER

NUMBER OF			-0-

SHARES		6	SHARED VOTING POWER
BENEFICIALLY
OWNED BY			599,549

EACH		7	SOLE DISPOSITIVE POWER
REPORTING
PERSON			-0-

WITH		8	SHARED DISPOSITIVE POWER

			599,549

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	599,549

10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

	o

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	3.5%

12	TYPE OF REPORTING PERSON

	IN

Page 5 of 16 pages.


CUSIP No.		81724W104	13G


1	NAME OF REPORTING PERSON I.R.S. Identification No. of Above Persons (Entities Only) F. Gibson Myers, Jr.


2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
	(a) o
	(b) þ

3	SEC USE ONLY



4	CITIZENSHIP OR PLACE OF ORGANIZATION

	U.S.

		5	SOLE VOTING POWER

NUMBER OF			-0-

SHARES		6	SHARED VOTING POWER
BENEFICIALLY
OWNED BY			599,549

EACH		7	SOLE DISPOSITIVE POWER
REPORTING
PERSON			-0-

WITH		8	SHARED DISPOSITIVE POWER

			599,549

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	599,549

10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

	o

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	3.5%

12	TYPE OF REPORTING PERSON

	IN

Page 6 of 16 pages.


CUSIP No.		81724W104	13G


1	NAME OF REPORTING PERSON I.R.S. Identification No. of Above Persons (Entities Only) Kevin A. Fong


2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
	(a) o
	(b) o

3	SEC USE ONLY



4	CITIZENSHIP OR PLACE OF ORGANIZATION

	U.S.

		5	SOLE VOTING POWER

NUMBER OF			-0-

SHARES		6	SHARED VOTING POWER
BENEFICIALLY
OWNED BY			-0-

EACH		7	SOLE DISPOSITIVE POWER
REPORTING
PERSON			-0-

WITH		8	SHARED DISPOSITIVE POWER

			-0-

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	-0-

10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

	o

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	0.0%

12	TYPE OF REPORTING PERSON

	IN

Page 7 of 16 pages.


CUSIP No.		81724W104	13G


1	NAME OF REPORTING PERSON I.R.S. Identification No. of Above Persons (Entities Only) William D. Unger


2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
	(a) o
	(b) þ

3	SEC USE ONLY



4	CITIZENSHIP OR PLACE OF ORGANIZATION

	U.S.

		5	SOLE VOTING POWER

NUMBER OF			-0-

SHARES		6	SHARED VOTING POWER
BENEFICIALLY
OWNED BY			599,549

EACH		7	SOLE DISPOSITIVE POWER
REPORTING
PERSON			-0-

WITH		8	SHARED DISPOSITIVE POWER

			599,549

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	599,549

10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

	o

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	3.5%

12	TYPE OF REPORTING PERSON

	IN

Page 8 of 16 pages.


CUSIP No.		81724W104	13G


1	NAME OF REPORTING PERSON I.R.S. Identification No. of Above Persons (Entities Only) Wendell G. Van Auken, III


2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
	(a) o
	(b) þ

3	SEC USE ONLY



4	CITIZENSHIP OR PLACE OF ORGANIZATION

	U.S.

		5	SOLE VOTING POWER

NUMBER OF			-0-

SHARES		6	SHARED VOTING POWER
BENEFICIALLY
OWNED BY			599,549

EACH		7	SOLE DISPOSITIVE POWER
REPORTING
PERSON			-0-

WITH		8	SHARED DISPOSITIVE POWER

			599,549

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	599,549

10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

	o

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	3.5%

12	TYPE OF REPORTING PERSON

	IN

Page 9 of 16 pages.


CUSIP No.		81724W104	13G


1	NAME OF REPORTING PERSON I.R.S. Identification No. of Above Persons (Entities Only) A. Grant Heidrich, III


2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
	(a) o
	(b) þ

3	SEC USE ONLY



4	CITIZENSHIP OR PLACE OF ORGANIZATION

	U.S.

		5	SOLE VOTING POWER

NUMBER OF			-0-

SHARES		6	SHARED VOTING POWER
BENEFICIALLY
OWNED BY			599,549

EACH		7	SOLE DISPOSITIVE POWER
REPORTING
PERSON			-0-

WITH		8	SHARED DISPOSITIVE POWER

			599,549

9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	599,549

10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

	o

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	3.5%

12	TYPE OF REPORTING PERSON

	IN

Page 10 of 16 pages.

Item 1.


		(a)		Name of Issuer:

				SenoRx, Inc.

		(b)		Address of Issuer’s Principal Executive Offices:

				3 Morgan
				Irvine, CA 92618

Item 2.


		(a)		Name of Persons Filing:

				Mayfield IX Management, L.L.C.
				Mayfield IX, a Delaware Limited Partnership
				Mayfield Associates Fund IV, a Delaware Limited Partnership
				Yogen K. Dalal
				F. Gibson Myers, Jr.
				Kevin A. Fong
				William D. Unger
				Wendell G. Van Auken, III
				A. Grant Heidrich, III

		(b)		Address of Principal Business Office:

				c/o Mayfield Fund
				2800 Sand Hill Road, Suite 250
				Menlo Park, CA 94025

		(c)		Citizenship:

				Mayfield IX, a Delaware Limited Partnership and Mayfield Associates Fund IV, a
				Delaware Limited Partnership, are Delaware limited partnerships.
				Mayfield IX Management, L.L.C. is a Delaware limited liability company.
				The individuals listed in Item 2(a) are U.S. citizens.

		(d)		Title of Class of Securities:

				Common Stock

		(e)		CUSIP Number:

				81724W104

Page 11 of 16 pages.


Item 3.		If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a:

		Not applicable


Item 4.		Ownership.

		The information regarding ownership as set forth in Items 5-9 of Pages 2-10 hereto, is hereby incorporated by reference.

		For a summary of total ownership by all Reporting Persons, see Exhibit 3 hereto.


Item 5.		Ownership of Five Percent or Less of a Class.

		If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following þ


Item 6.		Ownership of More than Five Percent on Behalf of Another Person.

		Not applicable.


Item 7.		Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

		Not applicable.


Item 8.		Identification and Classification of Members of the Group.

		Not applicable.


Item 9.		Notice of Dissolution of Group.

		Not applicable.


Item 10.		Certification.

		Not applicable.

Page 12 of 16 pages.

SIGNATURES

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: February 12, 2009


	MAYFIELD IX MANAGEMENT, L.L.C.
	By:	/s/ James T. Beck
		James T. Beck, Authorized Signatory

	MAYFIELD IX, A DELAWARE LIMITED PARTNERSHIP
	By:	Mayfield IX Management, L.L.C.
		Its General Partner


	By:	/s/ James T. Beck
		James T. Beck, Authorized Signatory

	MAYFIELD ASSOCIATES FUND IV, A DELAWARE LIMITED PARTNERSHIP
	By:	Mayfield IX Management, L.L.C.
		Its General Partner

	By:	/s/ James T. Beck
		James T. Beck, Authorized Signatory

	YOGEN K. DALAL
	By:	/s/ James T. Beck
		James T. Beck, Attorney In Fact

	F. GIBSON MYERS, JR.
	By:	/s/ James T. Beck
		James T. Beck, Attorney In Fact


	/s/ Kevin A. Fong
	KEVIN A. FONG

Page 13 of 16 pages.


	WILLIAM D. UNGER
	By:	/s/ James T. Beck
		James T. Beck, Attorney In Fact

	WENDELL G. VAN AUKEN, III
	By:	/s/ James T. Beck
		James T. Beck, Attorney In Fact

	A. GRANT HEIDRICH, III
	By:	/s/ James T. Beck
		James T. Beck, Attorney In Fact

Page 14 of 16 pages.

EXHIBIT INDEX


Exhibit 1 -		“JOINT FILING AGREEMENT” is hereby incorporated by reference to Exhibit 1 to the Statement on Schedule 13G dated February 14, 2008.

Exhibit 2 -		“POWERS OF ATTORNEY” are hereby incorporated by reference to Exhibit 2 to the Statement on Schedule 13G dated February 14, 2008.

Exhibit 3 -		OWNERSHIP SUMMARY

Page 15 of 16 pages.

EXHIBIT 3


	Number of						Percent of Class
	Shares			Number of Shares			Beneficially
Name of Reporting Person	(Direct)			(Indirect)			Owned (1)
Mayfield IX Management, L.L.C.		-0-			599,549	(2)(3)		3.5	%
Mayfield IX, a Delaware Limited Partnership		569,574	(2)		-0-			3.3	%
Mayfield Associates Fund IV, a Delaware Limited Partnership		29,975	(3)		-0-			0.2	%
Yogen K. Dalal		-0-			599,549	(4)		3.5	%
F. Gibson Myers, Jr.		-0-			599,549	(4)		3.5	%
Kevin A. Fong		-0-			-0-	(5)		0.0	%
William D. Unger		-0-			599,549	(4)		3.5	%
Wendell G. Van Auken, III		-0-			599,549	(4)		3.5	%
A. Grant Heidrich, III		-0-			599,549	(4)		3.5	%
TOTAL		599,549						3.5	%


(1)		The respective percentages set forth in this column were obtained by dividing the number of shares by the aggregate number of shares outstanding as of December 31, 2008.

(2)		Represents shares held directly by Mayfield IX, a Delaware Limited Partnership (“Mayfield IX”), of which Mayfield IX Management, L.L.C. (“Mayfield IX Management”) is the General Partner.

(3)		Represents shares held directly by Mayfield Associates Fund IV, a Delaware Limited Partnership (“Mayfield Associates IV”), of which Mayfield IX Management is the General Partner.

(4)		Includes shares held directly by Mayfield IX and Mayfield Associates IV. Yogen K. Dalal, F. Gibson Myers, Jr., William D. Unger, Wendell G. Van Auken III and A. Grant Heidrich, III are Managing Directors of Mayfield IX Management, which is the general partner of Mayfield IX and Mayfield Associates IV. The Reporting Persons may be deemed to have shared voting and dispositive power over the shares which are or may be deemed to be beneficially owned by Mayfield IX and Mayfield Associates IV, but each disclaims such beneficial ownership.

(5)		Effective February 8, 2008, Mr. Fong ceased to be a Managing Director of Mayfield IX Management.

Page 16 of 16 pages.